The Sentinel Bus is largely divided into Guides and Sentinels. Neither Sentinels nor Guides are human beings. While Sentinels typically know they've been triggered by a runaway, Guides don't have a runaway, so they're no different from ordinary people. If a Sentinels run away, the Guide can calm them with guidance. Of course, guidance alone won't stop the runaway completely.
Even in the Sentinelverse, there are commonly grades. There are S-grade, SS-grade, and SSS-grade. The higher the grade, the more painful the Sentinel is. Furthermore, the guide and the Sentinel must be of the same grade. An S-grade Sentinel is more effective guided by an S-grade Guide than by a D-grade Guide. Typically, imprints are formed through a physical connection, though sometimes they are formed on paper. Once a Sentinel is imprinted, they are forced to work with the Guide who created the imprint.